Endocrine Abstracts

Introduction: The importance of the liver-X receptors (LXRs) in the maintenance of cholesterol homeostasis within the testis has yet to be fully characterised. By 7 months of age, Lxrα/β double knockout male mouse (Lxrα/β DKO) develops sterility with aberrations in testosterone production and lipid homeostasis. However, the underlying testicular LXR-regulated pathways are not well understood.Aim: The aim of this study was to further u...

Background: Bile acids (BAs) are end-products of cholesterol catabolism, which act as signalling molecules to regulate glucose, lipid and energy metabolism. BAs activate several receptors including the ligand sensitive transcription factor Farnesoid X receptor (FXR) and the membrane G-protein coupled receptor, TGR5. Besides the organs physiologically in contact with BAs, like the gut and liver, BA-receptors are also expressed in cholesterol-rich steroidogenic tissues, such as ...